Is Your Body Begging for a Detox? 10 Warning Signs from Your Liver and Kidneys

By BINDHULATHA HARIKUMAR -
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  Is Your Body Begging for a Detox? 10 Warning Signs from Your Liver and Kidneys In today’s fast-paced world, our bodies are constantly exposed to toxins—from the processed food we eat to the polluted air we breathe and even the stress we experience. Two of the hardest-working detoxifying organs in our bodies are the liver and kidneys. They work around the clock to filter waste, balance bodily fluids, and keep us feeling energized and healthy. But what happens when these organs become overloaded? Just like any other part of our body, the liver and kidneys can show signs of distress when they’re overburdened. Ignoring these warning signs can lead to fatigue, chronic illness, and even long-term damage. In this blog post, we’ll explore the top 10 warning signs that your liver and kidneys might be crying out for a detox—and how you can naturally support them to restore your vitality. Understanding the Role of the Liver and Kidneys Liver: The Body’s Natural Filter The liver ...
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PHYSIOLOGY OF WOUND HEALING : SHORT

By BINDHULATHA HARIKUMAR -

 

PHYSIOLOGY OF WOUND HEALING


When your skin is injured, a complex process called wound healing begins. It involves different cells, tissues, and biochemical signals working together to repair the damaged area.

INFLAMMATORY PHASE

The first stage is called the inflammatory phase, which begins immediately after the injury and can last up to a week. This phase is characterized by the release of chemicals that cause blood vessels to dilate and white blood cells to move into the wound. The white blood cells help to remove any bacteria or debris from the injury site.

PROLIFERATIVE PHASE

The second stage is called the proliferative phase, which can last up to three weeks. During this phase, the body produces new blood vessels to supply the wound with oxygen and nutrients. Fibroblasts, which are cells that produce collagen, are also activated to help rebuild the damaged tissue. The wound begins to close, and new tissue starts to grow.

MATURATION OR REMODELLING PHASE

The final stage is called the maturation or remodeling phase, which can last for up to two years. During this phase, the new tissue becomes stronger and more flexible, and the wound becomes less noticeable. The collagen fibers reorganize, and the scar tissue matures.

Overall, wound healing is a complex process that involves many different steps and cell types. It is important to keep the wound clean and protected to promote proper healing. If you have a wound that is not healing properly, it is important to seek medical attention.

Flow chart on the physiology of wound healing:

A Comprehensive Review of Advanced Biopolymeric Wound Healing Systems - ScienceDirect

 

 

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1.     Wound occurrence

2.     Hemostasis (blood clotting)

3.     Inflammatory phase

·        Release of inflammatory mediators (histamine, cytokines, and chemokines)

·        Migration of immune cells (neutrophils and macrophages)

·        Removal of debris and bacteria

4.     Proliferative phase

·        Granulation tissue formation

·        Angiogenesis (formation of new blood vessels)

·        Epithelialization (formation of new skin)

·        Formation of extracellular matrix (ECM)

·        Fibroblast proliferation and collagen synthesis

5.     Remodeling phase

·        Collagen remodeling and cross-linking

·        Scar formation

·        Increased tensile strength of the wound.

6.     Wound closure

Explanation of the flow chart:

The physiology of wound healing is a complex process that involves various stages, starting from the occurrence of the wound to its closure. The first stage in wound healing is hemostasis, which is the process of blood clotting to stop bleeding. Once the bleeding stops, the inflammatory phase begins.

During the inflammatory phase, various inflammatory mediators such as histamine, cytokines, and chemokines are released, leading to the migration of immune cells such as neutrophils and macrophages to the site of injury. These immune cells remove debris and bacteria, preparing the wound for the next phase.

The proliferative phase is characterized by the formation of granulation tissue, angiogenesis, epithelialization, and the formation of extracellular matrix (ECM). Fibroblasts proliferate and synthesize collagen, which provides the tensile strength required for wound closure.

The final stage of wound healing is the remodeling phase, where the newly synthesized collagen undergoes remodeling and cross-linking, leading to the formation of a scar. The scar tissue has increased tensile strength, which is necessary for wound closure and tissue repair.

CONCLUSION

In conclusion, wound healing is a complex process that involves various stages, including hemostasis, inflammation, proliferation, and remodeling, leading to wound closure and tissue repair.

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